I urge you to consider the merits of the combination of metformin and aspirin to treat and or mitigate cancer in its various forms. The merits of the combination are obvious from a search of pubmed.org for eg cancer and aspirin , cancer and metformin, aspirin metformin and cancer.
While the Hiram Maxim school of healthcare is guaranteed to be 100 percent effective, I think that you might wish to see others at least start with a more nuanced approach. As you may observe both components of the combination are cheap, safe and inexpensive and thus the only people that will study the combination are those confronted with the failure of other things who have not yet decided to try hot lead healthcare as taught by Dr. Hiram Maxim whose great invention will live on and make money for many more years.
Open Biol. 2013 Jan 8;3(1):120144. doi: 10.1098/rsob.120144.
Oxidants, antioxidants and the current incurability of metastatic cancers.
Source
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA. berejka@cshl.eduAbstract
The vast majority of all agents used to directly kill cancer
cells (ionizing radiation, most chemotherapeutic agents and some
targeted therapies) work through either directly or indirectly
generating reactive oxygen species that block key steps in the cell
cycle. As mesenchymal cancers evolve from their epithelial cell
progenitors, they almost inevitably possess much-heightened amounts of
antioxidants that effectively block otherwise highly effective oxidant
therapies. Also key to better understanding is why and how the
anti-diabetic drug metformin
(the world's most prescribed pharmaceutical product) preferentially
kills oxidant-deficient mesenchymal p53(- -) cells. A much faster
timetable should be adopted towards developing more new drugs effective
against p53(- -) cancers.
- PMID:
- 23303309
- [PubMed - indexed for MEDLINE]
- PMCID:
- PMC3603456
Cancer Prev Res (Phila). 2013 Aug;6(8):801-10. doi: 10.1158/1940-6207.CAPR-13-0058-T. Epub 2013 Jun 14.
Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling.
Source
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.Abstract
Metformin is the most commonly prescribed drug for type II diabetes and is associated with decreased cancer risk. Previously, we showed that metformin
prevented tobacco carcinogen (NNK)-induced lung tumorigenesis in a
non-diabetic mouse model, which was associated with decreased
IGF-I/insulin receptor signaling but not activation of AMPK in lung
tissues, as well as decreased circulating levels of IGF-I and insulin.
Here, we used liver IGF-I-deficient (LID) mice to determine the
importance of IGF-I in NNK-induced lung tumorigenesis and
chemoprevention by metformin. LID mice had decreased lung tumor multiplicity and burden compared with wild-type (WT) mice. Metformin further decreased lung tumorigenesis in LID mice without affecting IGF-I levels, suggesting that metformin can act through IGF-I-independent mechanisms. In lung tissues, metformin
decreased phosphorylation of multiple receptor tyrosine kinases (RTK)
as well as levels of GTP-bound Ras independently of AMPK. Metformin also diminished plasma levels of several cognate ligands for these RTKs. Tissue distribution studies using [(14)C]-metformin showed that uptake of metformin was high in liver but four-fold lower in lungs, suggesting that the suppression of RTK activation by metformin
occurs predominantly via systemic, indirect effects. Systemic
inhibition of circulating growth factors and local RTK signaling are new
AMPK-independent mechanisms of action of metformin that could underlie its ability to prevent tobacco carcinogen-induced lung tumorigenesis.
De Blasio’s father committed suicide while suffering from cancer
But public records uncovered by The Post show that his dad’s life didn’t just turn tragic in the decades after he lost part of his leg in the Battle of Okinawa – it ended tragically as well.
On a July morning in 1979, Warren Wilhelm was found with a self-inflicted gun wound in a parked car outside the Rocky River Motel in New Milford, Conn.
The 61-year-old, who lived 35 miles away in New Haven after having split from de Blasio’s mother in Massachusetts a decade earlier, was suffering from late-stage terminal cancer at the time, according to public records.
“The local police received a call at 8:24 a.m. from a subject stating that he or she had found a man dead in vehicle,” reads a brief Aug. 2, 1979 article in the New Milford Times. “The police said their investigation revealed that the wound had been self-inflicted with a rifle.”
A death certificate filed in the town clerk’s office shows that the medical examiner found not just a chest wound, but also “carcinoma of the lung and metastases.”
The one-page report says Wilhelm was born in Staten Island, had gotten divorced from Maria de blasio and was working as a freelance writer at the time of his death.
It names Bill’s older brother, Steven, as the one who provided all the information to the medical examiner’s office.
De Blasio has never publicly discussed his father’s death, and has only spoken generally about the deeply personal pain of seeing his father succumb to alcoholism and disappear from home when Bill was 7. His parents divorced the following year.
De Blasio declined The Post’s request to discuss his relationship with his father, who died when Bill had just graduated high school in Cambridge, Mass., at age 18.
His older brothers Steven Wilhelm, a journalist in Seattle, WA, and Don Wilhelm, of Brookline, Mass., could not be reached for comment.
In his most detailed words on the subject, de Blasio told WBGO-FM last year that he respected his late father “immensely,” particularly for his heroic war service.
“I think honestly, as we now know about veterans who return, [he] was going through physically and mentally a lot from that point on. And by the time I came along in the beginning of the 60s, he was unfortunately in a downward spiral,” de Blasio said.
“So this was someone I can now say I have immense, immense respect for what he did, but I also saw, unfortunately, a lot of the bad side,” de Blasio told the radio station. “He was an alcoholic, and my mother and father broke up very early on in the time I came along, and I was brought up by my mother’s family — that’s the bottom line — the de Blasio family.”
His closeness to his mother’s side eventually prompted him to change his given name – of Warren Wilhelm, Jr. – first to Warren de Blasio-Wilhelm, and then finally to Bill de Blasio.
His mom, an author who also served during World War II in the Office of War Information, for years lived down the block from de Blasio and his family in Park Slope, Brooklyn.
She passed away in 2007.
De Blasio issued a statement saying, “While this has been a private part of my family’s life, it is now clear a media story will soon emerge. My father tragically ended his life while battling terminal cancer in 1979.”
Power politics: LIPA's broken promises
LIPA protests
Read the final Moreland Commission report
Read the LIPA reorganization bill
Search LIPA contracts
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