Curr Opin Immunol. 2018 Dec;55:89-96. doi: 10.1016/j.coi.2018.09.016. Epub 2018 Nov 15.
Bridging the gap between vaccination with Bacille Calmette-Guérin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis.
Abstract
At the end of past century, when the prevailing view was that treatment of autoimmunity required immune suppression, experimental evidence suggested an approach of immune-stimulation such as with the BCG vaccine in type 1 diabetes (T1D) and multiple sclerosis (MS). Translating these basic studies into clinical trials, we showed the following: BCG harnessed the immune system to 'permanently' lower blood sugar, even in advanced T1D; BCG appeared to delay the disease progression in early MS; the effects were long-lasting (years after vaccination) in both diseases. The recently demonstrated capacity of BCG to boost glycolysis may explain both the improvement of metabolic indexes in T1D, and the more efficient generation of inducible regulatory T cells, which counteract the autoimmune attack and foster repair mechanisms.
Copyright © 2018 Elsevier Ltd. All rights reserved.
- PMID:
- 30447407
- DOI:
- 10.1016/j.coi.2018.09.016
#PresidentCuomo trends as governor’s star status rises over coronavirus response in failed attempt to wipe out his loss to the woman of the wandering dago food truck that we paid for
Wandering Dago, Inc. v. Destito, No. 16-622 (2d Cir. 2018)
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Justia Opinion Summary
WD filed suit against OGS, alleging that defendants violated its rights under the First Amendment, the Equal Protection Clause, and the New York State Constitution by denying WD's applications to participate as a food truck vendor in the Lunch Program based on its ethnic-slur branding. The Second Circuit reversed the district court's grant of summary judgment for defendant, holding that defendants' action violated WD's equal protection rights and its rights under the New York State Constitution. In this case, it was undisputed that defendants denied WD's applications solely because of its ethnic-slur branding. In Matal v. Tam, 137 S. Ct. 1744 (2017), the Supreme Court clarified that this action amounted to viewpoint discrimination and, if not government speech or otherwise protected, was prohibited by the First Amendment. The court rejected defendants' argument that their actions were unobjectionable because they were either part of OGS's government speech or permissible regulation of a government contractor's speech.
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New York Gov. Andrew Cuomo gives updates on the spread of the coronavirus during a news conference in Albany today. Hans Pennink
Wandering Dago, Inc. v. Destito, No. 16-622 (2d Cir. 2018)
Annotate this Case
Justia Opinion Summary
WD filed suit against OGS, alleging that defendants violated its rights under the First Amendment, the Equal Protection Clause, and the New York State Constitution by denying WD's applications to participate as a food truck vendor in the Lunch Program based on its ethnic-slur branding. The Second Circuit reversed the district court's grant of summary judgment for defendant, holding that defendants' action violated WD's equal protection rights and its rights under the New York State Constitution. In this case, it was undisputed that defendants denied WD's applications solely because of its ethnic-slur branding. In Matal v. Tam, 137 S. Ct. 1744 (2017), the Supreme Court clarified that this action amounted to viewpoint discrimination and, if not government speech or otherwise protected, was prohibited by the First Amendment. The court rejected defendants' argument that their actions were unobjectionable because they were either part of OGS's government speech or permissible regulation of a government contractor's speech.
Gov. Andrew Cuomo’s daily televised press briefings on the coronavirus have him looking presidential, according to some social media fans.
“Proud to have Gov Cuomo not only leading NY but also the country. #PresidentCuomo,”@RastaRusty tweeted. “We’re[sic] already tested more people than any city . . .”
“President Cuomo is really raising the bar for leadership [right now], and I’m here for it. #PresidentCuomo#CoronavirusPandemic,” @j_m_storm wrote.
At a news conference earlier in the day, Cuomo kept up his commanding style, and seemed to direct it at millennials and Gen Zers: “There’s a significant amount of non-compliance, especially in New York City, especially in parks. I’m gonna go down there today, I want to see what the situation is myself.”
Telling people who think they have the superpower to avoid the virus, he scolded: “You are wrong.” That phrase also began trending on Twitter Saturday.
Some say he’s outshined President Trump.
“Sorry, getting my info from #PresidentCuomo, thanks,” @stylewriterNYC tweeted.
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