please help see that BCG is available to all who wish same in NY, Oklahoma and beyond.
BCG is safe, effective, inexpensive and useful for many purposes. See faustmanlab.org and pubmed.org fasutman dl
I trust that you share my appreciation of BCG .

You can shoot me with BCG ( I will supply same) and put me on You Tube. America has its healthcare priorities backwards. Cheap and effective ammunition and firearms and expensive and unavailable, dangerous, and often harmful healthcare

I will also be glad to discuss Susan Beyha and William Thomas Beyha with you. See eg the federal personnel file of the first named author of The Lancet p.106 Jan. 14, 1978. You have the appropriate governmental access to obtain same. The Lancet describes the treatment of the cause of causalgia. The patient was Mrs. J. Edward Spike Jr. and her personal physician was Mark Altschule of Harvard.

Result Filters

2012;7(8):e41756. doi: 10.1371/journal.pone.0041756. Epub 2012 Aug 8.

Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes.

Faustman DL, Wang L, Okubo Y, Burger D, Ban L, Man G, Zheng H, Schoenfeld D, Pompei R, Avruch J, Nathan DM.

Source

The Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America. faustman@helix.mgh.harvard.edu

Abstract

BACKGROUND:

No targeted immunotherapies reverse type 1 diabetes in humans. However, in a rodent model of type 1 diabetes, Bacillus Calmette-Guerin (BCG) reverses disease by restoring insulin secretion. Specifically, it stimulates innate immunity by inducing the host to produce tumor necrosis factor (TNF), which, in turn, kills disease-causing autoimmune cells and restores pancreatic beta-cell function through regeneration.

METHODOLOGY/PRINCIPAL FINDINGS:

Translating these findings to humans, we administered BCG, a generic vaccine, in a proof-of-principle, double-blind, placebo-controlled trial of adults with long-term type 1 diabetes (mean: 15.3 years) at one clinical center in North America. Six subjects were randomly assigned to BCG or placebo and compared to self, healthy paired controls (n = 6) or reference subjects with (n = 57) or without (n = 16) type 1 diabetes, depending upon the outcome measure. We monitored weekly blood samples for 20 weeks for insulin-autoreactive T cells, regulatory T cells (Tregs), glutamic acid decarboxylase (GAD) and other autoantibodies, and C-peptide, a marker of insulin secretion. BCG-treated patients and one placebo-treated patient who, after enrollment, unexpectedly developed acute Epstein-Barr virus infection, a known TNF inducer, exclusively showed increases in dead insulin-autoreactive T cells and induction of Tregs. C-peptide levels (pmol/L) significantly rose transiently in two BCG-treated subjects (means: 3.49 pmol/L [95% CI 2.95-3.8], 2.57 [95% CI 1.65-3.49]) and the EBV-infected subject (3.16 [95% CI 2.54-3.69]) vs.1.65 [95% CI 1.55-3.2] in reference diabetic subjects. BCG-treated subjects each had more than 50% of their C-peptide values above the 95(th) percentile of the reference subjects. The EBV-infected subject had 18% of C-peptide values above this level.

CONCLUSIONS/SIGNIFICANCE:

We conclude that BCG treatment or EBV infection transiently modified the autoimmunity that underlies type 1 diabetes by stimulating the host innate immune response. This suggests that BCG or other stimulators of host innate immunity may have value in the treatment of long-term diabetes.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00607230.

Comment in

Targeting innate immunity to treat long-term type 1 diabetes. [Regen Med. 2012]

I look forward to you stopping by Nassau OTB's Branch in Franklin Square on Hempstead Turnpike to discuss same.

Editorial

More Money to Treat AIDS Abroad

By THE EDITORIAL BOARD

Published: November 27, 2013

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At a time when partisan bickering has crippled Congress, it is encouraging to find agreement on the important issue of curbing the global AIDS epidemic.

Today's Editorials

Editorial: Silencing Dissent in Egypt (November 28, 2013)
Editorial: The Perils of Polystyrene (November 28, 2013)
Editorial: Room at the Table (November 28, 2013)

Connect With Us on Twitter

For Op-Ed, follow @nytopinion and to hear from the editorial page editor, Andrew Rosenthal, follow @andyrNYT.

A bipartisan group of 40 senators and representatives has urged President Obama to double the number of people abroad who will be treated for infections with H.I.V., the AIDS virus, by the end of 2016 under an American program that helps foreign governments in poor and low-income countries finance efforts to fight the disease.

The group wants to set a new goal of 12 million people under treatment with antiviral drugs by the end of 2016, double the six million currently under treatment. With no vaccine to prevent AIDS yet available, treatment is an effective way to slow the epidemic because it reduces the risk that an infected person will spread the virus to others.

The group — led by Senator Tom Coburn, Republican of Oklahoma, who is a physician, and Representative Barbara Lee, a Democrat of California — includes Senators John McCain, Marco Rubio, Michael Enzi, Lamar Alexander and Bob Corker, all Republicans. The Democrats who have signed on include Senators Charles Schumer, Kirsten Gillibrand and Elizabeth Warren, and Representative Debbie Wasserman Schultz, who is chairwoman of the Democratic National Committee.

It’s not clear what the cost of raising the treatment goal might be, but Congress and the Obama administration should cooperate in finding the money, either by reprogramming existing funds or providing additional appropriations. The administration had been seeking, and House and Senate appropriations committees had approved, $4 billion for fiscal year 2014 to support the program helping foreign governments, but the budget battles in Congress make it likely that far less will be available.

The United States also joins other governments and private organizations in financing the Global Fund to Fight AIDS, Tuberculosis and Malaria. Next week, the fund is scheduled to hold a conference in Washington, at which it hopes to raise $15 billion in pledges from donors to cover the next three years. The United States is by far the biggest contributor to the fund. Other nations need to contribute their fair share.

In the long run, treating infected people before they get sick makes economic sense. It keeps them productive and supporting their families, reduces the cost of caring for those who might otherwise become sick and prevents new infections. It is also the humane thing to do.

Meet The New York Times’s Editorial Board »

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UPDATED August 2, 2013

The New York Times Editorial Board

The editorial board is composed of 19 journalists with wide-ranging areas of expertise. Their primary responsibility is to write The Times’s editorials, which represent the voice of the board, its editor and the publisher. The board is part of the Times’s editorial department, which is operated separately from the Times newsroom, and includes the Letters to the Editor and Op-Ed sections.

Insert Homeless Headline Here

By LAWRENCE DOWNES

Nov. 28, 2013

>>> Rigshospitalet <news@meltwaterpress.com> 9/3/2012 9:27 AM >>>

Press release

3rd of September 2012

Tuberculosis vaccine - a new remedy for allergies and asthma in children?
M Can a vaccine against tuberculosis help combat asthma and eczema in Danish children early in life? This will now be examined in a comprehensive Danish research study.
From September 2012, thousands of Danish pregnant women will receive an invitation to allow their newborns to take part in a sensational trial.
The tuberculosis vaccine was removed from the vaccine program in Denmark during the 1980s, however new research indicates that the vaccine can improve the health of children.
Research carried out in developing countries shows that the health of infants who have been given the tuberculosis vaccine (BCG/Calmette) at birth is improved and the babies have a better survival rate than those who have not been given the vaccine. The vaccine also seems to have a preventive effect against asthma and atopic dermatitis.
Results are so striking that they cannot be explained by the fact that the children did not catch tuberculosis. Therefore, researchers assess the vaccine to have a general positive effect on the immune system, which means that children are less sick, and have less atopic dermatitis, asthma and allergies.
Whether this positive effect also can benefit Danish children will now be examined in a large Danish research project headed by Lone Graff Stensballe, Paediatrician from the Department of Paediatrics and Adolescent Medicine at Rigshospitalet.
The research project will run for three years, starting in September 2012, where 4,300 infants and their parents will be followed through interviews, examinations, and, for 300 of the children, blood tests as well. The project will comprise five PhD courses and a research collaboration with obstetricians, paediatricians, midwives, nurses and laboratory technicians from the three hospitals taking part in the project.
“We are very excited about this unique opportunity to improve the health of Danish children early in life,” says Lone Graff Stensballe. “Unfortunately, we have seen large increases in admissions, consumption of medicines, asthma, eczema and allergies among Danish children. We hope to curb these increases with the new research project.”
The research project will be carried out at Rigshospitalet in collaboration with Hvidovre Hospital, Kolding Sygehus Lillebælt and the new Centre for Vitamins and Vaccines at SSI (Statens Serum Institut).

For further information and interviews, please contact:
Lone Graff Stensballe
Head of Research
Paediatrician, Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Denmark
Telephone: +45 6022 8092 E-mail: lone.graff.stensballe@rh.regionh.dk

Rigshospitalet - a part of Copenhagen University Hospital

Rigshospitalet – a part of Copenhagen University Hospital – is Denmark'sleading hospital for patients needing highly specialized treatment. Rigshospitalet serves all of Denmark, Greenland and the Faroe Islands within almost all specialties and sub-specialties of medicine and surgery.

Afmelding: Ønsker du ikke længere at få tilsendt e-mails fra Rigshospitalet via Meltwater Press, venligst klik: [her]. Afmelding kan tage op til 2 arbejdsdage.

Hvis du ønsker at kontakte Meltwater Press, kan du kontakte Meltwater Press på:
Meltwater Group Christian IX's Gade 10, 2. 1111 København K
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Andrew Rosenthal, Editor

Andrew Rosenthal, the editorial page editor of The New York Times, is in charge of the paper's opinion pages, both in the newspaper and online. He oversees the editorial board, the Letters and Op-Ed departments, as well as the Editorial and Op-Ed sections of NYTimes.com. The editorial department of the paper is completely separate from the news operations and Mr. Rosenthal answers directly to the publisher, Arthur Sulzberger Jr.
He is assisted by Deputy Editorial Page Editors Terry Tang, for the editorial page, and Trish Hall, for the Op-Ed Page, and by Tom Feyer, the Letters editor.
Under his direction, the 18 members of the board prepare the paper's editorials. The board holds regular meetings to discuss current issues. The editorials are written by individual board members in consultation with their colleagues, and are edited by Mr. Rosenthal and Ms. Tang.
Mr. Rosenthal became editorial page editor on Jan. 8, 2007. He was deputy editorial page editor since September 2003. Previously he served as assistant managing editor for news and foreign editor of The Times. He also served as national editor for six months in 2000, supervising coverage of the presidential elections and the post-election day recount, and as Washington editor. As a Washington correspondent, Mr. Rosenthal covered the Bush administration, the 1988 and 1992 presidential elections and the Persian Gulf War.
Prior to joining The Times in March 1987, Mr. Rosenthal worked at the Associated Press, where he served as Moscow bureau chief. Born in New Delhi, India, Mr. Rosenthal graduated from the University of Denver with a B.A. degree in American history in 1978.

Terry Tang, Deputy Editorial Page Editor

Terry Tang joined the Times in 1997. She has been editor of the Op-Ed page, an editorial writer covering law, health care and national issues, deputy technology editor, major beats editor for Metro news and an editor at Room for Debate. She was previously a columnist and editorial writer at the Seattle Times, and a staff writer at the Seattle Weekly. Ms. Tang has a B.A. in economics from Yale University and a J.D. from New York University School of Law. She was a Nieman Fellow at Harvard in 1992-1993.

Robert B. Semple Jr., Associate Editor

Robert Semple joined the Washington Bureau of The Times in the fall of 1963. He covered housing and civil rights during the Johnson administration, spent a year covering President Johnson himself, and served as White House correspondent during Richard Nixon's first term. He served thereafter as deputy national editor (1973-75), London bureau chief (1975-77), foreign editor (1977-82), editor of the Op-Ed Page (1982-88) and associate editor of the Editorial Page (1988 to present). He received the Pulitzer Prize in 1996 for his editorials on environmental issues.
Mr. Semple was born in St. Louis, raised in Michigan and educated at Andover, Yale and the University of California, where he received a master's degree in history in 1961.

David Firestone, Projects Editor, National Politics, the White House and Congress

@fstonenyt

David Firestone, who joined the editorial board in 2010, has worked for The New York Times since 1993. He began as Queens bureau chief, and has also been City Hall bureau chief, Public Lives columnist, a national correspondent based in Atlanta, a Washington correspondent, and deputy metropolitan editor. He has covered numerous political campaigns and the 2000 presidential recount in Florida.
Most recently, he was deputy national editor, supervising the National Desk's coverage of Hurricane Katrina and the South as well as legal and economic issues. He has also been a reporter for New York Newsday, where he covered the conflict in Bosnia and the attacks on Israel during the first Gulf War; the Dallas Times Herald; and the Kansas City Star. He grew up in Kansas City and is a graduate of the University of Missouri School of Journalism. He is married, with two sons, and lives in Brooklyn.

Vikas Bajaj, Business, International Economics

@vikasbajaj

Vikas Bajaj has worked at The New York Times since 2005. Before joining the editorial board in 2012, he was a correspondent based in Mumbai, India. He previously covered housing and financial markets for the Business section in New York. Born in Mumbai, Mr. Bajaj grew up there and in Bangkok, and he received a bachelor’s in journalism from Michigan State University. He came to The Times from The Dallas Morning News.

Philip M. Boffey, Science

Philip M. Boffey is an editorial writer at The New York Times. He formerly served as a reporter, science and health editor and deputy editorial page editor. Mr. Boffey was a member of two reporting teams that won Pulitzer Prizes: the first in 1986 for a series on the "Star Wars" missile defense system, the second in 1987 for coverage of the Challenger space shuttle disaster. He has been president of the National Association of Science Writers and is a director of the Council for the Advancement of Science Writing. Mr. Boffey is the author of "The Brain Bank of America," an investigation of the National Academy of Sciences, published in 1975.
Born in East Orange, N.J., Mr. Boffey received an A.B. degree, magna cum laude, in history, from Harvard College in 1958.

Francis X. Clines, National Politics, Congress, Campaign Finance

Before joining the editorial board in 2002, Francis X. Clines spent 40 years as a reporter for The Times on the city, national and foreign news staffs. His assignments ranged from City Hall to Appalachia, from Ireland to Uzbekistan, from the Reagan White House to Communism's last stand in the Kremlin. Born in Brooklyn, N.Y., he won the Meyer Berger Award for his "About New York" columns, as well as a Polk Award for coverage of the collapse of the Soviet Union.

Lawrence Downes, Immigration, Veterans Issues

Lawrence Downes, who joined the editorial board in 2004, has worked for The New York Times since 1993. He served on the National desk as enterprise editor and as deputy political editor during the 2000 presidential campaign. From 1998 to 2000, Mr. Downes was a weekend editor on the Metro desk and, before that, deputy weekend editor and copy editor. Mr. Downes was a copy editor at Newsday from 1992 to 1993 and at the Chicago Sun-Times from 1989 to 1992. Mr. Downes received a B.A. degree in English from Fordham University in 1986. He also attended the University of Missouri School of Journalism from 1987 to 1989.

Carol Giacomo, Foreign Affairs

@giacomonyt

Carol Giacomo, a former diplomatic correspondent for Reuters in Washington, covered foreign policy for the international wire service for more than two decades before joining The Times editorial board in August 2007. In her previous position, she traveled over 1 million miles to more than 100 countries with eight secretaries of state and various other senior U.S. officials. In 2009, she won the Georgetown University Weintal Prize for diplomatic reporting. She is a member of the Council on Foreign Relations. In 1999-2000, she was a senior fellow at the U.S. Institute of Peace, researching U.S. economic and foreign policy decision-making during the Asian financial crisis. She has been a guest lecturer at the U.S. National War College, among other academic institutions. Born and raised in Connecticut, she holds a B.A. in English Literature from Regis College, Weston, Mass. She began her professional journalism career at the Lowell Sun in Lowell, Mass., and later worked for the Hartford Courant in the city hall, state capitol and Washington bureaus.

Mira Kamdar, International Affairs

@mirakamdar

Mira Kamdar lives in Paris and is a faculty member at the École de Journalisme at Sciences Po. She teaches in the master's program jointly managed with the Paris School of International Affairs. She is the author of "Planet India: the Turbulent Rise of the Largest Democracy" and "Motiba’s Tattoos: A Granddaughter’s Journey Into her Indian Family’s Past." She has been a senior fellow at the World Policy Institute since 1992 and an associate fellow at the Asia Society in New York. Ms. Kamdar has written for many publications, including The Washington Post, Foreign Affairs, Foreign Policy, The Caravan (New Delhi), Le Monde Diplomatique, Courrier International and The New York Times's India Ink blog. She has a bachelor's degree from Reed College in Portland, Ore., and a Ph.D. in French literature from the University of California, Berkeley.

Verlyn Klinkenborg, Agriculture, Environment, Culture

Verlyn Klinkenborg has been a member of the editorial board since 1997. He was born in Meeker, Colo., in 1952 and grew up in Iowa and California. Then he came East and never got away again. He has a Ph.D. in English Literature from Princeton University and teaches at Pomona College and Yale University. He is the author of six books of nonfiction: Making Hay (1986), The Last Fine Time (1991), The Rural Life (2003), Timothy: Or, Notes of an Abject Reptile (2006), Several Short Sentences About Writing (2012), and More Scenes From The Rural Life (2013). He lives on a small farm in Columbia County, New York. Over the years, he has written about many subjects for the editorial board, including the editorial essays called "The Rural Life." His main fields are agriculture, environmental issues, the natural world, and all non-human species.

Juliet Lapidos, Culture

@julietlapidos

Juliet Lapidos joined The Times in 2011 and edits the Taking Note blog. Before coming to the newspaper, she was a culture editor at Slate. She holds a B.A. in comparative literature from Yale University and an M.Phil. in English literature from the University of Cambridge, where she was a Gates Scholar.

Eleanor Randolph, New York State, Northeast Region, Media

@EleanorRandolph

Eleanor Randolph is a native of Florida, a graduate of Emory University and veteran journalist who began working at a newspaper in Pensacola, Fla., in 1968. She has covered national politics and the media for The Washington Post and the Los Angeles Times, among others. Her articles have appeared in Vogue, Esquire, the New Republic and other magazines. After working from 1991 to 1993 in Moscow, she wrote a book on Russian life called "Waking the Tempests." A member of The Times editorial staff since 1998, she is the author of the "Fixing Albany" series on state government.

Dorothy Samuels, Law, Civil Rights, National Affairs

A member of the editorial board since 1984, Dorothy Samuels writes on a wide array of legal and social policy issues. Prior to joining The Times, she briefly practiced corporate law with a big Wall Street firm, leaving there to pursue her interests in public policy and journalism. For four years, Ms. Samuels served as executive director of the New York Civil Liberties Union, the largest affiliate of the national A.C.L.U. In 2001, in a change of pace, she published a comic novel, "Filthy Rich." Ms. Samuels is a graduate of Bryn Mawr College and Northeastern University School of Law.

Serge Schmemann, International Affairs

Serge Schmemann joined the Times in 1980. He served as the editorial page editor of the International Herald Tribune in Paris from 2003 to 2012. He has been a Times correspondent and bureau chief in Moscow, Bonn, Jerusalem and the United Nations. He served as the deputy foreign editor in New York from 1999 to 2001. Mr. Schmemann received the Pulitzer Prize in 1991 for coverage of the reunification of Germany, and an Emmy in 2003 for his work on a television documentary about the Israeli-Palestinian conflict. He was previously a reporter with the Associated Press. Mr. Schmemann is a graduate of Harvard College and holds an M.A. from Columbia University, as well as an honorary doctorate from Middlebury College. He was born in Paris, is married and has three children.

Brent Staples, Education, Criminal Justice, Economics

Brent Staples joined The Times editorial board in 1990. His editorials and essays are included in dozens of college readers throughout the United States and abroad. Before joining the editorial page, he served as an editor of The New York Times Book Review and an assistant editor for metropolitan news. Mr. Staples holds a Ph.D. in psychology from the University of Chicago and is author of "Parallel Time," a memoir, which was a finalist for the Los Angeles Times Book Prize and winner of the Anisfield-Wolf Book Award.

Masaru Tamamoto, International Affairs

Masaru Tamamoto lives in Yokohama, Japan. He has been a senior fellow at the World Policy Institute, research associate at Cambridge University, advanced research fellow at Harvard, MacArthur Foundation fellow in international peace and security at Princeton, and visiting fellow at Tokyo University. He taught at the American University in Washington and was the director of the Center for Asian Studies. He also has been a visiting professor at Ritsumeikan University in Kyoto. After graduating from Brown University with a degree in international relations, he went on to earn a Ph.D. with distinction from Johns Hopkins University.

Teresa Tritch, Economic Issues, Tax Policy

Before joining the editorial board in 2004, Teresa Tritch spent 12 years at Money magazine, as a staff writer, Washington, D.C., bureau chief and senior editor, covering politics, finance and taxes. She has also been a contributing editor for the Stanford Social Innovation Review, covering nonprofits, and for the Gallup Management Journal, covering workplace issues, as well as co-editor of a book on Iraq, "America at War," a joint project of CBS and Simon and Schuster. Ms. Tritch, a Los Angeles native, holds a B.A. in German from UCLA and an M.S. in Journalism from Columbia University. In 2000, she was a Knight-Bagehot fellow in Business and Economics Journalism at Columbia.

David C. Unger, Foreign Affairs

David C. Unger was born and raised in Brooklyn. He is a product of the New York City public school system and worked for three years as an elementary school teacher in Staten Island and Brooklyn. After studying modern history at Cornell University, the University of Wisconsin and the University of Texas, he joined The Times in 1977 as a news clerk for the editorial board. He has traveled widely on four continents and is now the paper's senior editorial writer on foreign affairs. He is the author of "The Emergency State" (2012).

Jesse Wegman, The Supreme Court, Legal Affairs

@jessewegman

Jesse Wegman joined the editorial board in 2013. He was previously a senior editor at The Daily Beast and Newsweek, a legal news editor at Reuters, and the managing editor of The New York Observer. In 2010, he received a Soros Justice Fellowship to write a book about jailhouse lawyers. He graduated from New York University School of Law in 2005. Before that, he was a producer and reporter for several National Public Radio programs.

Thursday, November 28, 2013

Dear Doctor Tom Coburn

PubMed