sarcoma on the house no charge

if you treat with humira temicade enbrel etcand lower the levels of tnf alpha the consequence are predictable and injurious because you are mechanistically doing the wrong thing

says who?


see pubmed.org faustman dl until you find the paper(s) obliquely referred to above

Cell Mol Life Sci. 2005 Aug;62(16):1850-62.

The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis.

Kodama S1, Davis M, Faustman DL.

Author information

Abstract

Excess levels of tumor necrosis factor-alpha (TNF-alpha) have been associated with certain autoimmune diseases. Under the rationale that elevated TNF-alpha levels are deleterious, several anti-TNF-alpha therapies are now available to block the action of TNF-alpha in patients with autoimmune diseases with a chronic inflammatory component to the destructive process. TNF-alpha antagonists have provided clinical benefit to many patients, but their use also is accompanied by new or aggravated forms of autoimmunity. Here we propose a mechanistically based hypothesis for the adverse events observed with TNF-alpha antagonists, and argue for the opposite therapeutic strategy: to boost or restore TNF-alpha activity as a treatment for some forms of autoimmunity. Activation defects in the transcription factor nuclear factor kappaB leave autoreactive T cells sensitive to TNF-alpha-induced apoptosis. Treatment with TNF-alpha, by destroying autoreactive T cells, appears to be a highly targeted strategy to interrupt the pathogenesis of type 1 diabetes, lupus and certain forms of autoimmunity.

note also uspto.gov inventor search faustman faustmanlab.org


who cares? certainly not jay jacobs and joseph g cairo who simply play to win

Lora Webster is a wife, mother, cancer survivor, and Paralympian.  Born in Phoenix, AZ, raised in Lincoln, NE, and now a 10 year resident of Point Lookout, she has been an active member of her community.  As an advocate for the physically different, she has spoken at many school and charity events, including the Nassau County Games for the Physically Challenged, about her experiences as an amputee and Paralympian.

At the age of 11, Lora was diagnosed with osteosarcoma (bone cancer) in her left leg, and as a result became an amputee.  An avid volleyball player post cancer, she has been a member of the US National Sitting Volleyball Team since February of 2003, competing and medaling in every Paralympic Games since 2004, including a gold medal in Rio in 2016.

After putting school on hold to focus on volleyball and children, Lora graduated from Stony Brook University with a Sociology degree in May 2017, earning special remarks from University President Stanley as well as being the guest speaker at her department’s ceremony.

As a wife and mom of 3 young children, Lora is an active volunteer with the PTA and school events.  Her family is her greatest motivation in making positive changes to the community.