Sunday, May 17, 2020

what does he have to say about the

use of BCG for corona virus and or autoimmune diseases ?

 2018 Dec;55:89-96. doi: 10.1016/j.coi.2018.09.016. Epub 2018 Nov 15.

Bridging the gap between vaccination with Bacille Calmette-Guérin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis.

Ristori G1, Faustman D2, Matarese G3, Romano S4, Salvetti M5.

Abstract

At the end of past century, when the prevailing view was that treatment of autoimmunity required immune suppression, experimental evidence suggested an approach of immune-stimulation such as with the BCG vaccine in type 1 diabetes (T1D) and multiple sclerosis (MS). Translating these basic studies into clinical trials, we showed the following: BCG harnessed the immune system to 'permanently' lower blood sugar, even in advanced T1D; BCG appeared to delay the disease progression in early MS; the effects were long-lasting (years after vaccination) in both diseases. The recently demonstrated capacity of BCG to boost glycolysis may explain both the improvement of metabolic indexes in T1D, and the more efficient generation of inducible regulatory T cells, which counteract the autoimmune attack and foster repair mechanisms.


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 2018 Dec;55:89-96. doi: 10.1016/j.coi.2018.09.016. Epub 2018 Nov 15.

Bridging the gap between vaccination with Bacille Calmette-Guérin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis.

Ristori G1, Faustman D2, Matarese G3, Romano S4, Salvetti M5.

Abstract

At the end of past century, when the prevailing view was that treatment of autoimmunity required immune suppression, experimental evidence suggested an approach of immune-stimulation such as with the BCG vaccine in type 1 diabetes (T1D) and multiple sclerosis (MS). Translating these basic studies into clinical trials, we showed the following: BCG harnessed the immune system to 'permanently' lower blood sugar, even in advanced T1D; BCG appeared to delay the disease progression in early MS; the effects were long-lasting (years after vaccination) in both diseases. The recently demonstrated capacity of BCG to boost glycolysis may explain both the improvement of metabolic indexes in T1D, and the more efficient generation of inducible regulatory T cells, which counteract the autoimmune attack and foster repair mechanisms.









Exclusive: Lack of immunity means China is vulnerable to another wave of coronavirus, top adviser warns


David Culver Profile


By David Culver and Nectar Gan, CNN
Updated 12:31 AM ET, Sun May 17, 2020 




GUANGZHOU, CHINA: China's top Severe Acute Respiratory Syndrome (SARS) expert Zhong Nanshan, in his office at the Guangzhou Institute of Respiratory Diseases 10 June 2005, in Guangzhou, southern China's Guangdong province. AFP PHOTO/GOH CHAI HIN (Photo credit should read GOH CHAI HIN/AFP via Getty Images)
































































































































(CNN)China still faces the "big challenge" of a potential second wave of Covid-19 infections, the country's top respiratory authority has warned, with the lack of immunity among the community a serious concern as the race to develop a vaccine continues.
Dr. Zhong Nanshan, the Chinese government's senior medical adviser and the public face of the country's fight against Covid-19, also confirmed in an exclusive interview with CNN on Saturday that local authorities in Wuhan, the city where the novel coronavirus was first reported in December, had suppressed key details about the magnitude of the initial outbreak.
China has reported more than 82,000 coronavirus cases, with at least 4,633 deaths, according to data from the country's National Health Commission (NHC). The number of new infections surged quickly in late January, prompting city lockdowns and nationwide travel bans.
By early February, China was reporting as many as 3,887 fresh cases a day. A month later, however, daily cases had dropped into the double digits -- while in the US, the number of daily infections skyrocketed, from 47 new cases on March 6 to 22,562 by the end of the month.
    Having now largely contained the virus, life in China is slowly returning to normal. Lockdowns have eased and some schools and factories have reopened across the country.
    Authorities in Wuhan have ordered mass Covid-19 testing for all 11 million residents after a new cluster of cases emerged earlier this month.
    Authorities in Wuhan have ordered mass Covid-19 testing for all 11 million residents after a new cluster of cases emerged earlier this month.
    But Zhong said Chinese authorities should not be complacent, with the danger of a second wave of infections looming large. Fresh clusters of coronavirus cases have emerged across China in recent weeks, in Wuhan as well as the northeastern provinces of Heilongjiang and Jilin.
    "The majority of ... Chinese at the moment are still susceptible of the Covid-19 infection, because (of) a lack of immunity," Zhong said. "We are facing (a) big challenge, it's not better than the foreign countries I think at the moment."

    "They didn't like to tell the truth"

    Zhong is known as the "SARS hero" in China for combating the severe acute respiratory syndrome epidemic in 2003. This time around, he has led the country's coronavirus response -- especially in the critical early stages of the outbreak.
    On January 20, it was Zhong who confirmed on state broadcaster CCTV that the coronavirus can be transmitted between people, after Wuhan health authorities had maintained for weeks that there was no clear evidence for human-to-human transmission, and that the outbreak was "preventable and controllable."
    Heading a team of experts dispatched by the NHC to investigate the initial outbreak, Zhong visited Wuhan on January 18. He said that upon his arrival, he received many calls from doctors and former students, warning him that the situation was much worse than the official reports had claimed.
    "The local authorities, they didn't like to tell the truth at that time," Zhong said.
    "At the very beginning they kept silent, and then I said probably we have (a larger) number of people being infected."
    Zhong said he became suspicious when the number of officially reported cases in Wuhan remained at 41 for more than 10 days -- despite infections emerging overseas.
    "I didn't believe that result, so I (kept) asking and then, you have to give me the real number," he said. "I suppose they are very reluctant to answer my question."
    Zhong Nanshan speaks at a press conference in Beijing on January 20.
    Zhong Nanshan speaks at a press conference in Beijing on January 20.
    In Beijing two days later, on January 20, he was told the total number of cases in Wuhan was now 198, with three people killed and 13 medical workers infected.
    In a meeting with central government officials, including Chinese Premier Li Keqiang, that same day, he proposed to lock Wuhan down to contain the virus' spread.
    The move was unprecedented. The central government placed Wuhan under lockdown on January 23, canceling all flights, trains and buses in and out of the city, and blocking major highway entrances.
    The Wuhan lockdown was eventually lifted 76 days later.
    In an interview with CCTV on January 27, Wuhan mayor Zhou Xianwang admitted that his government did not disclose information on the coronavirus to the public "in a timely fashion," saying, "as a local government, we can only disclose information after being authorized."
    In February, China fired several senior officials amid widespread criticism of the local authorities' handling of the outbreak. They included the two officials in charge of the provincial health commission, as well as the Chinese Communist Party chiefs of Wuhan and Hubei province, according to China's state-run Xinhua News Agency.
    A woman wearing a face mask takes a rest on a bicycle along the East Lake in Wuhan after its lockdown was lifted.
    A woman wearing a face mask takes a rest on a bicycle along the East Lake in Wuhan after its lockdown was lifted.

    Lessons learned from SARS

    While Zhong acknowledged that the number of infections were initially under reported in Wuhan, he rejected accusations that China's official statistics remained unreliable even after the central government took control of the country's coronavirus response in late January.
    With the number of coronavirus deaths surpassing 87,000 in the US, President Donald Trump has publicly questioned the accuracy of China's death toll.
    But Zhong said the Chinese government had learned lessons from SARS 17 years ago, when it covered up "some of the outbreak... for two or three months."
    This time, he said, the central government announced that "all the cities, all the government departments, should report the true number of diseases -- so if you do not do that, you will be punished."
    "So since ... the 23rd of January, I think all the data ... will be correct," he added.
    Migrant workers in face masks wait outside the train station in Guangzhou, China, before returning home during the SARS outbreak in 2003.
    Migrant workers in face masks wait outside the train station in Guangzhou, China, before returning home during the SARS outbreak in 2003.
    Zhong said he was surprised by the numbers of infections and deaths in the US, adding that he felt some Western governments didn't take the coronavirus threat seriously early in the outbreak.
    "I think in some of the countries in Europe, or perhaps in the US, (the governments) suppose this kind of disease... is more or less like influenza, so that's wrong," he said.
    Zhong also rejected the theory pushed by Trump and US Secretary of State Mike Pompeo that the virus originated in a Wuhan laboratory.
    The Wuhan lab at the center of the US-China blame game: What we know and what we don't
    The Wuhan lab at the center of the US-China blame game: What we know and what we don't
    He said he had repeatedly asked Shi Zhengli, the lead virologist from the Wuhan Institute of Virology at the center of the Trump administration's accusations, about claims that the virus was created in her lab and accidentally leaked.
    "She said that's totally ridiculous, she had never been doing anything like that," said Zhong, who called Shi a "good friend."
    "She said based on their equipment and facilities and manpower... they were unable to do anything, any kind of artificial virus at this time."
    Zhong said that in early February, China's disease control authorities spent two weeks investigating Shi's lab for wrongdoing. They didn't find anything, he added.

    The pursuit of a vaccine

    With thousands of new coronavirus cases still being reported around the world every day -- and 300,000 dead since the pandemic began -- researchers are scrambling to develop a vaccine.
    Three US companies are already testing their vaccines on humans, according to the World Health Organization. They're still in phase 1 or phase 2 trials, which typically involve giving the vaccine to dozens or hundreds of study subjects.
      Zhong said three Chinese vaccines are under clinical trials in the country -- however a "perfect" solution was likely to be "years" away.
      "We have to test again and again and again ... by using different kinds of vaccines. It's too early to draw any conclusion which kind of vaccine is available for this kind of coronavirus ... that's why I suggest that the final approval of vaccine (will) take much longer," he said.







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