1. Please include the following in all references to MS
a)
Ristori
G, Romano S, Cannoni S, Visconti A, Tinelli E, Mendozzi L, Cecconi P,
Lanzillo R, Quarantelli M, Buttinelli C, Gasperini C, Frontoni M,
Coarelli G, Caputo D, Bresciamorra V, Vanacore N, Pozzilli C, Salvetti
M.
Neurology. 2014 Jan 7;82(1):41-8. doi: 10.1212/01.wnl.0000438216.93319.ab. Epub 2013 Dec 4.
Ann Neurol. 1995 Aug;38(2):147-54.
Reduced expression of peptide-loaded HLA class I molecules on multiple sclerosis lymphocytes.
Abstract
Lymphocytes
from patients with HLA class II-linked autoimmune diseases such as type
I diabetes, systemic lupus erythematosus, rheumatoid arthritis, and
Graves' have recently been shown to have a decrease in the expression of
self-peptide-filled HLA class I antigens on the surface of peripheral
lymphocytes. The human demyelinating diseases of multiple sclerosis
in some cases are also associated with the presence of certain HLA
class II genes, which may in turn be linked to genes in the class II
region that control class I expression. Hence, we studied fresh
peripheral blood mononuclear cells (PBMCs) and newly produced
Epstein-Barr virus (EBV)-transformed cell lines from multiple sclerosis patients for the class I defect. Unseparated PBMCs, as well as T cells, B cells, and macrophages from multiple sclerosis
patients had a decrease in the amount of conformationally correct
peptide-filled HLA class I molecules on the cell surface compared with
matched controls detectable by flow cytometry. To demonstrate the
independence of this defect from exogenous serum factors, newly produced
EBV-transformed cell lines from B cells of patients with multiple sclerosis
maintained the defect. In addition, DR2 +/+, +/-, and -/-
EBV-transformed B cells from these patients similarly demonstrated the
self-antigen presentation defect. Analysis of a set of discordant multiple sclerosis
twins revealed the class I defect was exclusively found on the affected
twin lymphocytes, suggesting a role of this class I complex in disease
expression. These data indicate that multiple sclerosis patients have abnormal presentation of self-antigens.(ABSTRACT TRUNCATED AT 250 WORDS)
I would like to make a You Tube Video demonstrating the safety and efficacy of BCG for plaque psoriasis.
I have already observed that with one vaccination dose there is clearing. As an added benefit BCG confers protection against TB and multi-drug resistant TB.
3. See eg Ratner EJ The Lancet p.106 Jan. 14, 1978. You will find some cases of facial neuralgias concomittant with MS. I suggest that Ratner and his work have much to say about MS but for a short term/quick fix, Shoot BCG
Note BCG is safe for pregnant women.
See eg
>>> Rigshospitalet <news@meltwaterpress.com> 9/3/2012 9:27 AM >>>
Afmelding: Ønsker du ikke længere at få tilsendt e-mails fra Rigshospitalet via Meltwater Press, venligst klik: [her]. Afmelding kan tage op til 2 arbejdsdage.
Hvis du ønsker at kontakte Meltwater Press, kan du kontakte Meltwater Press på:
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The information transmitted in this email and any of its attachments is intended only for the person or entity to which it is addressed and may contain information concerning Cablevision and/or its affiliates and subsidiaries that is proprietary, privileged, confidential and/or subject to copyright. Any review, retransmission, dissemination or other use of, or taking of any action in reliance upon, this information by persons or entities other than the intended recipient(s) is prohibited and may be unlawful. If you received this in error, please contact the sender immediately and delete and destroy the communication and all of the attachments you have received and all copies thereof.
Please help see that BCG is available to all who seek same in NY
I would like to make a You Tube Video demonstrating the safety and efficacy of BCG for plaque psoriasis.
I have already observed that with one vaccination dose there is clearing. As an added benefit BCG confers protection against TB and multi-drug resistant TB.
3. See eg Ratner EJ The Lancet p.106 Jan. 14, 1978. You will find some cases of facial neuralgias concomittant with MS. I suggest that Ratner and his work have much to say about MS but for a short term/quick fix, Shoot BCG
Note BCG is safe for pregnant women.
See eg
>>> Rigshospitalet <news@meltwaterpress.com> 9/3/2012 9:27 AM >>>
 Press release |
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3rd of September 2012 |
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Tuberculosis vaccine - a new remedy for allergies and asthma in children? M Can a vaccine against tuberculosis help combat asthma and eczema in Danish children early in life? This will now be examined in a comprehensive Danish research study. From September 2012, thousands of Danish pregnant women will receive an invitation to allow their newborns to take part in a sensational trial. The tuberculosis vaccine was removed from the vaccine program in Denmark during the 1980s, however new research indicates that the vaccine can improve the health of children. Research carried out in developing countries shows that the health of infants who have been given the tuberculosis vaccine (BCG/Calmette) at birth is improved and the babies have a better survival rate than those who have not been given the vaccine. The vaccine also seems to have a preventive effect against asthma and atopic dermatitis. Results are so striking that they cannot be explained by the fact that the children did not catch tuberculosis. Therefore, researchers assess the vaccine to have a general positive effect on the immune system, which means that children are less sick, and have less atopic dermatitis, asthma and allergies. Whether this positive effect also can benefit Danish children will now be examined in a large Danish research project headed by Lone Graff Stensballe, Paediatrician from the Department of Paediatrics and Adolescent Medicine at Rigshospitalet. The research project will run for three years, starting in September 2012, where 4,300 infants and their parents will be followed through interviews, examinations, and, for 300 of the children, blood tests as well. The project will comprise five PhD courses and a research collaboration with obstetricians, paediatricians, midwives, nurses and laboratory technicians from the three hospitals taking part in the project. “We are very excited about this unique opportunity to improve the health of Danish children early in life,” says Lone Graff Stensballe. “Unfortunately, we have seen large increases in admissions, consumption of medicines, asthma, eczema and allergies among Danish children. We hope to curb these increases with the new research project.” The research project will be carried out at Rigshospitalet in collaboration with Hvidovre Hospital, Kolding Sygehus Lillebælt and the new Centre for Vitamins and Vaccines at SSI (Statens Serum Institut). For further information and interviews, please contact: Lone Graff Stensballe Head of Research Paediatrician, Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Denmark Telephone: +45 6022 8092 E-mail: lone.graff.stensballe@rh.regionh.dk |
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Afmelding: Ønsker du ikke længere at få tilsendt e-mails fra Rigshospitalet via Meltwater Press, venligst klik: [her]. Afmelding kan tage op til 2 arbejdsdage.
Hvis du ønsker at kontakte Meltwater Press, kan du kontakte Meltwater Press på:
Meltwater Group Christian IX's Gade 10, 2. 1111 København K
--------------------------------------------------------
The information transmitted in this email and any of its attachments is intended only for the person or entity to which it is addressed and may contain information concerning Cablevision and/or its affiliates and subsidiaries that is proprietary, privileged, confidential and/or subject to copyright. Any review, retransmission, dissemination or other use of, or taking of any action in reliance upon, this information by persons or entities other than the intended recipient(s) is prohibited and may be unlawful. If you received this in error, please contact the sender immediately and delete and destroy the communication and all of the attachments you have received and all copies thereof.
Please help see that BCG is available to all who seek same in NY
New York, NY
Headquarters 70 West 36th Street, 16th Floor New York, NY 10018 (212) 613-8020 ph (212) 613-8021 fx nyc "at" drugpolicy . org |
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