Wednesday, March 25, 2020

cuomo gives ny bettors an option to bet over the

internet or wire while the are locked down at home while nassau otb is closed

cuomo hates being third fiddle to the  .....one and the corona virus

if he read ristori in his spare time he would help many people




Sunday, April 12, 2020
Track CodeTrack NameEntryScratch1st Post
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SASANTA ANITA PARK72483:00 PM12:00 PMPDT
SUNSUNLAND PARK168242:30 PM12:30 PMMDTMt. Cristo Rey H.
TAMTAMPA BAY DOWNS72012:35 PM12:35 PM

 2018 Dec;55:89-96. doi: 10.1016/j.coi.2018.09.016. Epub 2018 Nov 15.

Bridging the gap between vaccination with Bacille Calmette-Guérin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis.

Ristori G1, Faustman D2, Matarese G3, Romano S4, Salvetti M5.

Abstract

At the end of past century, when the prevailing view was that treatment of autoimmunity required immune suppression, experimental evidence suggested an approach of immune-stimulation such as with the BCG vaccine in type 1 diabetes (T1D) and multiple sclerosis (MS). Translating these basic studies into clinical trials, we showed the following: BCG harnessed the immune system to 'permanently' lower blood sugar, even in advanced T1D; BCG appeared to delay the disease progression in early MS; the effects were long-lasting (years after vaccination) in both diseases. The recently demonstrated capacity of BCG to boost glycolysis may explain both the improvement of metabolic indexes in T1D, and the more efficient generation of inducible regulatory T cells, which counteract the autoimmune attack and foster repair mechanisms.
Copyright © 2018 Elsevier Ltd. All rights reserved.

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