BCG works well for MS, Type 1 diabetes, plaque psoriasis etc. BCG is not well known to Americans or American healthcare providers, but see eg faustmanlab.org and pubmed.org faustman dl or pubmed.org ristori + BCG.
What can you expect in a land of lawyers and liars?
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Bacillus Calmette-Guérin Suppresses Asthmatic Responses via CD4(+)CD25(+) Regulatory T Cells and Dendritic Cells.
Abstract
PURPOSE:
Bacillus Calmette-Guérin (BCG)
is known to suppress the asthmatic responses in a murine model of
asthma and to induce dendritic cells (DCs) maturation. Mature DCs play a
crucial role in the differentiation of regulatory T cells (Tregs),
which are known to regulate allergic inflammatory responses. To
investigate whether BCG regulates Tregs in a DCs-mediated manner, we analyzed in a murine model of asthma.
METHODS:
BALB/c mice were injected intraperitoneally with BCG or intravenously with BCG-stimulated
DCs and then sensitized and challenged with ovalbumin (OVA). Mice were
analysed for bronchial hyperresponsiveness (BHR), the influx of
inflammatory cells in the bronchoalveolar lavage (BAL) fluid, and
histopathological changes in the lung. To identify the mechanisms, IgE,
IgG1 and IgG2a in the serum were analysed and the CD25+ Tregs in the
mice were depleted with anti-CD25 monoclonal antibody (mAb).
RESULTS:
BCG and the transfer of BCG-stimulated
DCs both suppressed all aspects of the asthmatic responses, namely,
BHR, the production of total IgE and OVA-specific IgE and IgGs, and
pulmonary eosinophilic inflammation. Anti-CD25mAb treatment reversed
these effects.
CONCLUSIONS:
BCG can attenuate the allergic inflammation in a mouse model of asthma by a Tregs-related mechanism that is mediated by DCs.
KEYWORDS:
BCG; T-lymphocytes, regulatory; allergic inflammation; asthma; dendritic cells; mouse
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