1. Greece, Italy and Isis will supply BCG to all Americans with autoimmune diseases who can read and write and evaluate eg pubmed.org faustman dl, pubmed.org ristori + BCG , and faustmanlab.org . Those who are improved at little cost can then choose to pledge their allegiance to Greece, Italy or Isis. You might think that Obama would simply tell Faustman, make the peptide that prevents disease in situ and test it on volunteers in the US, Greece, or others.
2. Obama might simply see that metformin and aspirin are given to all who want same to treat their cancers. Obama might call James D Watson at Cold Spring Harbor and ask for a bibliography.
Obama Announces $215 Million Precision-Medicine Genetic Plan
Effort Seeks to Take Advantage of Technological Advances to Analyze People’s Full Genetic Makeups
Speaking at the White House, Mr. Obama called the $215 million Precision Medicine Initiative “one of the biggest opportunities for breakthroughs in medicine that we have ever seen.”
The gathering included genetics experts, patients, academics and government officials. Towering over everyone was basketball legend Kareem Abdul-Jabbar, who as a cancer patient was treated using precision medicine.
The initiative, which envisions accumulating genetic data on one million or more volunteers, would greatly expand the knowledge of people’s genetic makeups, known as their genomes. It would seek to decipher clues from genetic patterns across the broad population. Many details have yet to be ironed out—such as who will have access to the data under what conditions—but leading federal scientists said they expect researchers from academia, industry and government all to play crucial roles.
The $215 million in additional funding, included in the president’s budget for fiscal 2016, would go toward research by the National Institutes of Health, the NIH’s National Cancer Institute and the Food and Drug Administration. The NIH would get $130 million for the genetic mapping project, which would take advantage of technological advances that have made it possible—and relatively affordable—to analyze people’s full genetic makeups.
ENLARGE
Earlier
- Obama Meets 18-Year-Old Cancer Researcher, Among Other Science-Fair Achievers (May 27, 2014)
- Teen Elana Simon Helped Research Her Own Disease (Feb. 27, 2014)
“The way you know the moment is right,” the president said, “is you get bipartisan support for the idea.”
In a statement, Mr. Alexander said, “We have a real opportunity to work together and get a result so that cutting-edge medicine begins reaching patients more quickly.” He said he looked forward to hearing the plan’s specifics.
Rep. Fred Upton (R., Mich.), chairman of the House Energy & Commerce Committee, which plays a similar role in the House, said he and House Republicans hope “to get a bill to the president’s desk by the end of this year” that would incorporate GOP ideas. These would likely include faster approvals for new drugs and medical devices by the FDA, supported by the pharmaceutical and device industries.
In addition to the NIH funding, the National Cancer Institute would get $70 million to study genetic causes of cancer; the FDA would get $10 million to evaluate new diagnostic devices and drugs; and $5 million would be devoted to building the computing and privacy components of the genetic-data network.
At a Thursday briefing, NIH Director Francis Collins called the initiative “an exciting, but somewhat general plan.”
In an interview, he estimated that full genetic information now is known for 10,000 to 20,000 people. “A million [people] would be an enormous advance, particularly if it could be done in a coordinated fashion,” he said.
A human genome can be sequenced by machine for as little as $1,000, down from $400 million 15 years ago. Increased computing power means researchers can sort through reams of sequencing data and health records to find patterns linking specific genes to diseases.
Drugs that would attack these new genetic targets promise to modify the course of diseases, if not cure them, researchers say. But there would still be years of work to develop the drugs and prove they are safe and effective.
“This is a very important and necessary first step, but it is not sufficient,” said Jeffrey Leiden, chief executive of Vertex Pharmaceuticals Inc. After the cystic-fibrosis gene was discovered in 1989, it took Vertex until 2012 to get approval for the first drug treating one genetic mutation involved in the disease. About 1,650 patients in the U.S. with this mutation are candidates for the drug Kalydeco.
Some companies have already been undertaking genomic-data research efforts. In Iceland, deCODE Genetics is helping parent company Amgen Inc. to find genetic risk factors for diseases and fuel its early drug research. Regeneron Pharmaceuticals Inc. is collaborating with Geisinger Health System and other health networks to sequence 50,000 patients a year for its research.
Precision medicine already is transforming cancer treatment with drugs such as Roche Holding AG ’s Zelboraf. If a patient with melanoma, for instance, is found to have a mutation in a gene called BRAF, he may be prescribed Zelboraf, which targets the mutation. If the tumor doesn’t have that gene variant, doctors are likely to try something else rather than expose a patient to the cost and side effects of a drug that is unlikely to work. This is one of the tenets of precision medicine.
Write to Thomas M. Burton at tom.burton@wsj.com, Jonathan D. Rockoff at Jonathan.Rockoff@wsj.com and Ron Winslow at ron.winslow@wsj.com
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Results: 9
1.
Ristori G, Romano S, Coarelli G, Buscarinu MC, Salvetti M.
Neurology. 2014 Jul 22;83(4):381. No abstract available.
- PMID:
- 25184184
- [PubMed - indexed for MEDLINE]
2.
Ristori G, Romano S, Coarelli G, Buscarinu MC, Salvetti M.
Neurology. 2014 Jul 15;83(3):293. No abstract available.
- PMID:
- 25157390
- [PubMed - indexed for MEDLINE]
3.
Sethi NK, Ristori G, Romano S, Coarelli G, Buscarinu MC, Salvetti M.
Neurology. 2014 Jul 15;83(3):293. doi: 10.1212/01.wnl.0000452303.37990.ff. No abstract available.
- PMID:
- 25024446
- [PubMed - indexed for MEDLINE]
4.
Ristori
G, Romano S, Cannoni S, Visconti A, Tinelli E, Mendozzi L, Cecconi P,
Lanzillo R, Quarantelli M, Buttinelli C, Gasperini C, Frontoni M,
Coarelli G, Caputo D, Bresciamorra V, Vanacore N, Pozzilli C, Salvetti
M.
Neurology. 2014 Jan 7;82(1):41-8. doi: 10.1212/01.wnl.0000438216.93319.ab. Epub 2013 Dec 4.
- PMID:
- 24306002
- [PubMed - indexed for MEDLINE]
5.
The effect of Bacille Calmette-Guérin on the evolution of ne
1.
Ristori G, Romano S, Coarelli G, Buscarinu MC, Salvetti M.
Neurology. 2014 Jul 22;83(4):381. No abstract available.
- PMID:
- 25184184
- [PubMed - indexed for MEDLINE]
2.
Ristori G, Romano S, Coarelli G, Buscarinu MC, Salvetti M.
Neurology. 2014 Jul 15;83(3):293. No abstract available.
- PMID:
- 25157390
- [PubMed - indexed for MEDLINE]
3.
Sethi NK, Ristori G, Romano S, Coarelli G, Buscarinu MC, Salvetti M.
Neurology. 2014 Jul 15;83(3):293. doi: 10.1212/01.wnl.0000452303.37990.ff. No abstract available.
- PMID:
- 25024446
- [PubMed - indexed for MEDLINE]
4.
Ristori
G, Romano S, Cannoni S, Visconti A, Tinelli E, Mendozzi L, Cecconi P,
Lanzillo R, Quarantelli M, Buttinelli C, Gasperini C, Frontoni M,
Coarelli G, Caputo D, Bresciamorra V, Vanacore N, Pozzilli C, Salvetti
M.
Neurology. 2014 Jan 7;82(1):41-8. doi: 10.1212/01.wnl.0000438216.93319.ab. Epub 2013 Dec 4.
- PMID:
- 24306002
- [PubMed - indexed for MEDLINE]
5.
Paolillo A, Buzzi MG, Giugni E, Sabatini U, Bastianello S, Pozzilli C, Salvetti M, Ristori G.
J Neurol. 2003 Feb;250(2):247-8. No abstract available.
- PMID:
- 12622098
- [PubMed - indexed for MEDLINE]
6.
Rook GA, Ristori G, Salvetti M, Giovannoni G, Thompson EJ, Stanford JL.
Immunol Today. 2000 Oct;21(10):503-8. Review. No abstract available.
- PMID:
- 11071529
- [PubMed - indexed for MEDLINE]
7.
Ristori G, Buzzi MG, Sabatini U, Giugni E, Bastianello S, Viselli F, Buttinelli C, Ruggieri S, Colonnese C, Pozzilli C, Salvetti M.
Neurology. 1999 Oct 22;53(7):1588-9.
- PMID:
- 10534275
- [PubMed - indexed for MEDLINE]
8.
Henderson DA, Labusquire R, Nicholson CC, Rey M, Ristori C, Dow PJ, Saroso JS, Millar JD.
Paediatr Indones. 1972 Oct;12(10):409-26.
- PMID:
- 4679478
- [PubMed - indexed for MEDLINE]
9.
Ristori C.
Bol Oficina Sanit Panam. 1969 May;66(5):436-49. Spanish. No abstract available.
- PMID:
- 4239683
- [PubMed - indexed for MEDLINE]
Related citations
Watson JD.
Lancet. 2014 Mar 1;383(9919):841-3. doi: 10.1016/S0140-6736(13)62365-X. No abstract available.
- PMID:
- 24581668
- [PubMed - indexed for MEDLINE]
2.
Watson J.
Open Biol. 2013 Jan 8;3(1):120144. doi: 10.1098/rsob.120144.
- PMID:
- 23303309
- [PubMed - indexed for MEDLINE]
The US concept of personalized medicine should not consist of
1. Make them pay until they die and then replace them.
2. Administer the Gary Gilmore treatment in Utah.