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Your donation will directly support our Phase II research.
Raised to date: $20 million
Our total need: $25.2 million.
Raised to date: $20 million
Our total need: $25.2 million.
The Faustman Lab at Massachusetts General Hospital
Denise Faustman, MD, PhD, is Director of the Immunobiology Laboratory at the Massachusetts General Hospital (MGH) and an Associate Professor of Medicine at Harvard Medical School. Her current research focuses on discovering and developing new treatments for type 1 diabetes and other autoimmune diseases, including Crohn's disease, lupus, scleroderma, rheumatoid arthritis, Sjögren's syndrome, and multiple sclerosis. She is currently leading a human clinical trial program testing the efficacy of the BCG vaccine for reversal of long-term type 1 diabetes. Positive results from the Phase I study were reported in 2012.Dr. Faustman's type 1 diabetes research has earned her notable awards such as the Oprah Achievement Award for “Top Health Breakthrough by a Female Scientist” (2005), the "Women in Science Award" from the American Medical Women’s Association and Wyeth Pharmaceutical Company for her contributions to autoimmune disease research (2006), and the Goldman Philanthropic Partnerships/Partnership for Cures “George and Judith Goldman Angel Award” for research to find an effective treatment for type 1 diabetes (2011). Her previous research accomplishments include the first scientific description of modifying donor tissue antigens to change their foreignness. This achievement earned her the prestigious National Institutes of Health and National Library of Medicine “Changing the Face of Medicine” Award (2003) as one of 300 American physicians (one of 35 in research) honored for seminal scientific achievements in the United States.
Dr. Faustman earned her MD and PhD from Washington University School of Medicine in St. Louis, Missouri, and completed her internship, residency, and fellowships in Internal Medicine and Endocrinology at the Massachusetts General Hospital in Boston, Massachusetts.
A piece of Brookhaven Town Councilwoman Jane Bonner now lives in Tom D’Antonio.
It took but a moment for Bonner to decide to donate what turned out to be the third kidney transplant for her childhood friend.
“This wasn’t about me,” Bonner said in an interview. “God gives you two kidneys. Share the spare.”
The transplant almost certainly saved her friend’s life.
D’Antonio, who was diagnosed with type 1 diabetes as a child, developed kidney disease in 1988 when he was 29.
His declining health forced him to go on dialysis later that year until his then-girlfriend, whom he later married, tested positive as a kidney match. He then underwent a successful transplant.
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Transplants with matching donors do not come easily or quickly. More than 90,000 people nationwide are currently on the kidney transplant waiting list. It can take up to a decade before a successful transplant is performed, according to the Living Kidney Donor Network.
D’Antonio, 57, of Northport, said his diabetes later worsened and began damaging his new kidney. So he said he opted for a rare pancreas transplant procedure at Carolinas Medical Center in Charlotte, North Carolina, in 1999.
That transplant was a success, and life was good for D’Antonio, president of a Manhattan apparel company.
But as the years wore on, his donated kidney began to fail.
This time, his sister, Carla Minervini, 59, who was also a match, came to the rescue, donating a kidney to him in 2002.
“Everything was going along great; I got my life back,” D’Antonio said.
Until 2012.
That year, while riding a Long Island Rail Road train near Mineola, D’Antonio suffered a blood clot to his heart, causing him to go into cardiac arrest.
He said he was clinically dead and stopped breathing on his own for 14 minutes as an emergency medical technician performed CPR until first responders arrived and stabilized him.
“People normally have permanent brain damage without oxygen to the brain,” D’Antonio said. “My doctor said I was the luckiest and unluckiest patient he’s had.”
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His near-death experience eventually caught up to him.
Over the course of the next 18 months, his donated kidney started to fail because of the lack of oxygen during the cardiac arrest episode, D’Antonio said.
Bonner, 51, who describes D’Antonio as a 40-year-long friend for whom she used to donate blood when they were younger, came to his aid after hearing from him that he was in trouble. She didn’t need more than a few minutes to decide to go through with a transplant.
“I didn’t want to debate it,” Bonner said of donating one of her kidneys. The transplant took place on April 26 at NewYork-Presbyterian Hospital in Manhattan.
Bonner recently publicly talked about the transplant after making a full recovery from the surgery. She was able to return to her council obligations in 10 days.
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For D’Antonio, gratitude to his donor comes easily.
“It’s heroic at the very least. There was no second thought,” D’Antonio said of Bonner.
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