the double dummies shoild read the below and put it in their bong and smoke it to see if it imparts any wisdom
faustmanlab.org uspto.gov inventir search faustman pubmed.org ristori + bcg
De Blasio’s senior staff in near revolt over his
Curr Opin Immunol. 2018 Dec;55:89-96. doi: 10.1016/j.coi.2018.09.016.
Curr Opin Immunol. 2018 Dec;55:89-96. doi: 10.1016/j.coi.2018.09.016. Epub 2018 Nov 15.
Curr Opin Immunol. 2018 Dec;55:89-96. doi: 10.1016/j.coi.2018.09.016. Epub 2018 Nov 15.
Bridging the gap between vaccination with Bacille Calmette-Guérin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis.
Author information
Abstract
At the end of past century, when the prevailing view was that treatment of autoimmunity required immune suppression, experimental evidence suggested an approach of immune-stimulation such as with the BCG vaccine in type 1 diabetes (T1D) and multiple sclerosis (MS). Translating these basic studies into clinical trials, we showed the following: BCG harnessed the immune system to 'permanently' lower blood sugar, even in advanced T1D; BCG appeared to delay the disease progression in early MS; the effects were long-lasting (years after vaccination) in both diseases. The recently demonstrated capacity of BCG to boost glycolysis may explain both the improvement of metabolic indexes in T1D, and the more efficient generation of inducible regulatory T cells, which counteract the autoimmune attack and foster repair mechanisms.
2018 Nov 15.
At the end of past century, when the prevailing view was that treatment of autoimmunity required immune suppression, experimental evidence suggested an approach of immune-stimulation such as with the BCG vaccine in type 1 diabetes (T1D) and multiple sclerosis (MS). Translating these basic studies into clinical trials, we showed the following: BCG harnessed the immune system to 'permanently' lower blood sugar, even in advanced T1D; BCG appeared to delay the disease progression in early MS; the effects were long-lasting (years after vaccination) in both diseases. The recently demonstrated capacity of BCG to boost glycolysis may explain both the improvement of metabolic indexes in T1D, and the more efficient generation of inducible regulatory T cells, which counteract the autoimmune attack and foster repair mechanisms.
2018 Nov 15.
Bridging the gap between vaccination with Bacille Calmette-Guérin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis.
Author information
Abstract
At the end of past century, when the prevailing view was that treatment of autoimmunity required immune suppression, experimental evidence suggested an approach of immune-stimulation such as with the BCG vaccine in type 1 diabetes (T1D) and multiple sclerosis (MS). Translating these basic studies into clinical trials, we showed the following: BCG harnessed the immune system to 'permanently' lower blood sugar, even in advanced T1D; BCG appeared to delay the disease progression in early MS; the effects were long-lasting (years after vaccination) in both diseases. The recently demonstrated capacity of BCG to boost glycolysis may explain both the improvement of metabolic indexes in T1D, and the more efficient generation of inducible regulatory T cells, which counteract the autoimmune attack and foster repair mechanisms.
At the end of past century, when the prevailing view was that treatment of autoimmunity required immune suppression, experimental evidence suggested an approach of immune-stimulation such as with the BCG vaccine in type 1 diabetes (T1D) and multiple sclerosis (MS). Translating these basic studies into clinical trials, we showed the following: BCG harnessed the immune system to 'permanently' lower blood sugar, even in advanced T1D; BCG appeared to delay the disease progression in early MS; the effects were long-lasting (years after vaccination) in both diseases. The recently demonstrated capacity of BCG to boost glycolysis may explain both the improvement of metabolic indexes in T1D, and the more efficient generation of inducible regulatory T cells, which counteract the autoimmune attack and foster repair mechanisms.
coronavirus response
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When Mayor de Blasio dragged aides and members of his NYPD security detail to his Brooklyn YMCAMonday morning amidst the coronavirus outbreak, fellow fitness enthusiasts were coughing and sneezing — and a mentally ill person was walking around touching the equipment, a gym source said.
“It’s crazy that he made his staff and detail come with him to the gym and expose them like that,” the source said.
But the incident is just one example of the mayor’s disregard for the health of his staff during the crisis, multiple sources told The Post.
There’s also growing frustration from senior aides, who fault the mayor for dithering instead of making decisions, micromanaging instead of leading, and insisting he knows best instead of listening to others, three sources said.
‘Thank god for Cuomo,’ is a common refrain among the mayor’s staff, made only partly in jest, sources said.
That’s because Gov. Andrew Cuomo has taken the lead on the city’s COVID-19 response — canceling the St. Patrick’s Day Parade, shutting down large venues including Broadway, and even pushing the mayor to close public schools.
But instead of the big picture, the head of the City that Never Sleeps has insisted on proofing all public materials about the city’s COVID-19 response from press releases to ad campaigns, one source said.
“Instead of micromanaging his team he should be leading right now,” the source said.
And the mayor has tossed aside advice from staffers along the way. Staff repeatedly warned the mayor that prematurely announcing a possible shelter-in-place order Tuesday would cause unnecessary panic.
“He can’t handle the word ‘No,’ and it runs people down,” the source said.
“He is dismissive of everyone’s opinion around him,” added a second source.
“It’s very much his way or the highway in moments of crisis and he thinks he knows best,” the second source noted.
De Blasio described what a shelter-in-place order would look like for New York City at a City Hall press briefing and even refused to rule out a ban on travel out of the Big Apple.
Hours later Cuomo went on NY1 to reprimand the mayor.
“There’s not going to be any, ‘You must stay in your house,’ rule,” Cuomo said, calling the mayor’s remarks “counterproductive.” The governor explained that he wanted to craft a statewide plan before shutting down non-essential business in the Big Apple.
The governor eventually announced a statewide lockdown Friday, three days later.
Tensions are also frayed between de Blasio and many of his longtime aides.
But his chief of staff Emma Wolfe enjoys a better relationship with the Mayor.
“She is pushing back a lot harder than she normally does with him,” the second source said.
“Emma is an operative to the core and she has a relationship with the governor’s office. They respect her game and her political mind. She is able to forecast in terms of moves the governor’s office is going to make well before the mayor.
“She sees the need to be decisive in a moment like this and he doesn’t so she’s pushed him to get there,” the second source added.
The Post previously reported tensions between the mayor and senior health department officials including the city’s top doctor, Commissioner Oxiris Barbot.
A third source said de Blasio isn’t delegating decisions, which is why so many major announcements have had to be made by the governor.
The staff is “endlessly frustrated” by the mayor’s disregard for their health and micromanagement, the third source confirmed.
“He is a monster to deal with right now,” the second source explained.
“He’s incredibly condescending. He thinks he has a pulse on the emotions and feelings and concerns of everyday New Yorkers better than his staff, which is remarkable for a guy who lives in a mansion on the Upper East Side,” the source said.
Asked for comment, Freddi Goldstein, the mayor’s press secretary, said “this is an unprecedented crisis.”
“We are talking about massive decisions every day like closing schools for 1.1 million kids and closing businesses that give people their livelihoods. None of this is easy. The mayor gives every member of the team a chance to deliberate, but in the end only he can make decisions like this on behalf of 8.6 million New Yorkers,” Goldstein said.
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