Armed robbers,the reasonable md?
Money or your life
Drug companies
Money AND your life
Aspirin and Metformin for thinkers, readers, and selectively killing cancer cells , prophylaxis, and inhibiting metastasis.
Inexpensive enough for many and your kid can publish the results and practice medicine.
ENLARGE
Bristol-Myers Squibb R&D headquarters in Princeton, N.J. PHOTO: JOHN GREIM/LIGHTROCKET/GETTY IMAGES
“These drugs cost too much,” Leonard Saltz, chief of gastrointestinal oncology at Memorial Sloan Kettering Cancer Center, said in a speech heard by thousands of doctors here for the annual meeting of the American Society of Clinical Oncology.
Dr. Saltz’s remarks focused mainly on an experimental melanoma treatment made by Bristol-Myers Squibb Co., but he also criticized pricing more widely. He cited statistics showing that the median monthly price for new cancer drugs in the U.S. had more than doubled in inflation-adjusted dollars from $4,716 in the period from 2000 through 2004 to roughly $9,900 from 2010 through 2014. Dr. Saltz cited studies showing that the price increases haven’t corresponded to increases in the drugs’ effectiveness.
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Bristol-Myers’s new drug regimen showed significant benefit for melanoma patients in a study presented earlier on Sunday at ASCO’s plenary session. The regimen, which combines the drugs Yervoy and Opdivo, helped patients live for a median of 11.5 months without their disease getting worse.
Dr. Saltz said the combination regimen’s benefit was “truly, truly remarkable for a disease that five years ago we thought was virtually untreatable.” But he said that combining the drugs would cost around $295,000 a patient over nearly one year, which he called unsustainable. If all U.S. patients with metastatic cancer took drugs priced at $295,000 a year, it would cost $174 billion to treat them all for just one year, Dr. Saltz said.
“The unsustainably high prices of cancer drugs is a big problem, and it’s our problem,” Dr. Saltz said, calling on industry, physicians and insurers to work together with government to address the issue.
Dr. Saltz’s estimate of the combination’s cost was based on the average wholesale price of each drug individually and the average weight of a U.S. adult. Opdivo and Yervoy are already approved individually to treat melanoma patients, but not in combination with each other.
A Bristol-Myers spokeswoman said in an email that the company couldn’t comment on the drug combination’s potential price because it hadn’t yet been approved for melanoma patients. As more expensive cancer drugs get used in combination, some industry executives have raised the possibility of charging a discount to what the drugs would cost individually.
AstraZeneca PLC Chief Executive Pascal Soriot said in an interview that the company is exploring alternative pricing models for some of its drugs, such as discounting the price of two-drug combinations if they come to market.
Based on the drugs’ current recommended dose, Yervoy has a per-patient cost of $131,213 for a full course of treatment, the Bristol-Myers spokeswoman said. Opdivo costs about $150,000 annually per patient, she said.
Dr. Saltz’s speech was unusual because it was made at the meeting’s plenary session, where the field’s most significant scientific research is presented and which all meeting participants are expected to attend. An estimated 25,000 doctors and scientists attended this year’s meeting.
It is unprecedented for plenary speeches, which typically address scientific and medical issues, to substantially take on the topic of drug costs, said Alan Venook, a professor of medicine at the University of California San Francisco who planned the meeting’s scientific session and invited Dr. Saltz to speak.
The prominent venue for the speech was also unusual because, like many medical meetings, ASCO is sponsored by pharmaceutical companies and often focuses on highlighting advancements in drug development, said Dr. Venook. He said discussing drug prices there is “uncomfortable” because it could be seen as “biting the hand that feeds you.”
Doctors are also reluctant to antagonize the drug industry because they need pharmaceutical firms to invest in developing new medicines for patients, he said.
“It’s a tough balancing act for ASCO where the meeting is largely funded by pharma,” Dr. Venook said in an interview. “You can’t have a [plenary] talk trashing pharma, but you can have a talk by a respected person questioning it.”
There have been major advances in treating certain types of cancer in recent years, and pharmaceutical companies argue that their drugs’ prices represent their value to patients. Companies also note that they spend significant sums on research and development and on subsidizing patients’ out-of-pocket drug costs through so-called patient-assistance programs.
Robert Zirkelbach, a spokesman for the trade group Pharmaceutical Research and Manufacturers of America, said in an emailed statement that generic drugs and aggressive price negotiation by private insurers have kept overall drug spending in check. “This has led to tremendous—and sustainable—progress against cancer, including dramatic declines in cancer death rates and improved quality of life for patients,” he said.
In an interview prior to his speech, Dr. Saltz said there has been a taboo associated with doctors talking about drug prices, in part because doctors are expected to focus on what’s best for patients regardless of costs. But in recent years, drug prices have begun to more significantly impact patient care, he said. Patients are often expected to pay a percentage of the cost for high-priced therapies, forcing some patients to forgo effective therapies because of the financial burden, he said.
“All of the stakeholders involved need to stop pretending that price is something we don’t need to discuss, because it affects all of us, and it’s affecting our ability to deliver quality care to everyone,” Dr. Saltz said in the interview.
He said that one step toward controlling prices would be allowing Medicare to negotiate prices directly with pharmaceutical companies, which it is currently barred by law from doing. He also called for changing the way Medicare pays for infused drugs. Doctors currently receive a percentage of the drug’s total sales price. The payment method has created a conflict of interest because cancer doctors can make more money by using the most expensive drugs, he said.
“It’s hard to believe that any of us could not be influenced by that in some subtle way,” Dr. Saltz said in an interview. “It’s not to the patient’s advantage, and it’s not the way the system needs to work.”
—Peter Loftus
contributed to this article.
Write to Joseph Walker at joseph.walker@wsj.com
contributed to this article.
