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| United States Patent | 8,173,129 |
| Faustman | May 8, 2012 |
Methods and compositions for treating autoimmune diseases
The invention features methods for increasing or maintaining the number of functional cells of a predetermined type, for example, insulin producing cells of the pancreas, blood cells, spleen cells, brain cells, heart cells, vascular tissue cells, cells of the bile duct, or skin cells, in a mammal (e.g., a human patient) that has injured or damaged cells of the predetermined type.
| Inventors: | Faustman; Denise (Boston, MA) |
|---|---|
| Assignee: | The General Hospital Coporation (Boston, MA) |
| Family ID: | 30002891 |
| Appl. No.: | 12/632,452 |
| Filed: | December 7, 2009 |
| Document Identifier | Publication Date | |
|---|---|---|
| US 20100150893 A1 | Jun 17, 2010 | |
| Application Number | Filing Date | Patent Number | Issue Date | ||
|---|---|---|---|---|---|
| 10358664 | Feb 5, 2003 | 7628988 | |||
| 60392687 | Jun 27, 2002 | ||||
| Current U.S. Class: | 424/139.1; 424/142.1; 424/154.1; 424/577 |
| Current CPC Class: | A61K 35/26 (20130101); A61K 35/28 (20130101); A61K 35/39 (20130101); A61K 35/44 (20130101); A61K 38/1774 (20130101); A61K 38/191 (20130101); A61K 35/30 (20130101); A61K 39/04 (20130101); A61K 38/1866 (20130101); A61K 35/28 (20130101); A61K 35/44 (20130101); A61K 38/191 (20130101); A61K 38/1866 (20130101); A61K 35/39 (20130101); A61K 35/26 (20130101); A61K 38/1774 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101); A61K 2300/00 (20130101) |
| Current International Class: | A61K 39/40 (20060101); A61K 39/395 (20060101); A61K 35/26 (20060101) |
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Primary Examiner: Belyavskyi; Michail
Attorney, Agent or Firm:
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a divisional of, and claims priority from, U.S. Application Ser. No. 10/358,664, filed Feb. 5, 2003, now U.S. Pat. No. 7,628,988, which claims benefit of the filing date of U.S. Provisional Application No. 60/392,687, filed Jun. 27, 2002, each of which is incorporated by reference herein in its entirety.
What is claimed is:
1. A method for treating or stabilizing a disorder selected from the group consisting of celiac sprue-dermatitis, Crohn's disease, Graves' disease, hypothyroidism, lupus, multiple sclerosis, psoriasis, rheumatoid arthritis, sarcoidosis, Sjogren's syndrome, and ulcerative colitis in a human, said method comprising administering to said human a tumor necrosis factor-alpha (TNF-alpha) receptor II agonist antibody, wherein said TNF-alpha receptor II agonist antibody selectively kills blood cells with increased sensitivity to cell death, and wherein killing said blood cells treats or stabilizes said disorder.
2. The method of claim 1, wherein said disorder is celiac sprue-dermatitis.
3. The method of claim 1, wherein said disorder is Crohn's disease.
4. The method of claim 1, wherein said disorder is Graves' disease.
5. The method of claim 1, wherein said disorder is hypothyroidism.
6. The method of claim 1, wherein said disorder is lupus.
7. The method of claim 1, wherein said disorder is multiple sclerosis.
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